<?xml version="1.0" encoding="UTF-8"?><mets:mets xmlns:mets="http://www.loc.gov/METS/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:mads="http://www.loc.gov/mads/" xmlns:metsRights="http://cosimo.stanford.edu/sdr/metsrights/" xmlns:suj="http://www.theses.fr/namespace/sujets" xmlns:tef="http://www.abes.fr/abes/documents/tef" xmlns:tefextension="http://www.abes.fr/abes/documents/tefextension" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.loc.gov/METS/ http://www.abes.fr/abes/documents/tef/recommandation/tef_schemas.xsd">
<mets:metsHdr CREATEDATE="2012-10-09T07:31:14" ID="ABES.STAR.THESE_25455.METS_HEADER" LASTMODDATE="2026-07-20T03:07:29Z" RECORDSTATUS="valide">
<mets:agent ROLE="CREATOR">
<mets:name/>
<mets:note>Note</mets:note>
</mets:agent>
<mets:agent ROLE="DISSEMINATOR">
<mets:name>ABES</mets:name>
</mets:agent>
<mets:altRecordID ID="ABES.STAR.THESE_25455.METS_HEADER.ALTERNATE" TYPE=""/>
</mets:metsHdr>
<mets:dmdSec ID="ABES.STAR.THESE_25455.DESCRIPTION_BIBLIOGRAPHIQUE">
<mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_desc_these">
<mets:xmlData>
<tef:thesisRecord>
<dc:title xml:lang="fr">Rôle de la voie de signalisation du récepteur -1 des prokinéticines dans la fonction cardiaque et rénale : implication des cellules progénitrices</dc:title>
<dcterms:alternative xml:lang="en">Role of prokineticin receptor 1 signaling pathways in heart and kidney function : implication of progenitor cells</dcterms:alternative>
<dc:subject xml:lang="fr">Cardiomyopathie</dc:subject>
<dc:subject xml:lang="fr">Pathologie rénale</dc:subject>
<dc:subject xml:lang="fr">Communication cellulaire</dc:subject>
<dc:subject xml:lang="fr">Angiogenèse</dc:subject>
<dc:subject xml:lang="fr">Thérapie cellulaire</dc:subject>
<dc:subject xml:lang="fr">Epicardin (Tcf21, capsuline, POD1)</dc:subject>
<dc:subject xml:lang="fr">Cellules progénitrices</dc:subject>
<dc:subject xml:lang="fr">RCPG</dc:subject>
<dc:subject xml:lang="en">PKR1</dc:subject>
<dc:subject xml:lang="en">Epicardium</dc:subject>
<dc:subject xml:lang="en">Activation cells</dc:subject>
<dc:subject xml:lang="en">Differenciation cells</dc:subject>
<dc:subject xsi:type="dcterms:DDC">572.8</dc:subject>
<dc:subject xsi:type="dcterms:DDC">616.1</dc:subject>
<dc:subject xsi:type="dcterms:DDC">616.6</dc:subject>
<tef:sujetRameau xml:lang="fr">
<tef:vedetteRameauNomCommun>
<tef:elementdEntree autoriteExterne="027651665" autoriteSource="Sudoc">Cellules -- Interaction</tef:elementdEntree>
</tef:vedetteRameauNomCommun>
<tef:vedetteRameauNomCommun>
<tef:elementdEntree autoriteExterne="027817164" autoriteSource="Sudoc">Thérapeutique cellulaire</tef:elementdEntree>
</tef:vedetteRameauNomCommun>
<tef:vedetteRameauNomCommun>
<tef:elementdEntree autoriteExterne="027682102" autoriteSource="Sudoc">Myocardiopathies</tef:elementdEntree>
</tef:vedetteRameauNomCommun>
<tef:vedetteRameauNomCommun>
<tef:elementdEntree autoriteExterne="027242390" autoriteSource="Sudoc">Maladies rénales</tef:elementdEntree>
</tef:vedetteRameauNomCommun>
<tef:vedetteRameauNomCommun>
<tef:elementdEntree autoriteExterne="031464270" autoriteSource="Sudoc">Hormones peptidiques -- Récepteurs</tef:elementdEntree>
</tef:vedetteRameauNomCommun>
</tef:sujetRameau>
<dcterms:abstract xml:lang="fr">[...]Mon projet de Doctorat a donc visé à : 1. déterminer le rôle de la voie de signalisation PKR1 in vivo ; 2. la perte de la voie de signalisation PKR1 provenant de l’épicarde induit des dysfonctions cardiaques et rénales ; 3. mettre en évidence le rôle de PKR1 dans l’activation et la différentiation des cellules progénitrices.[...]</dcterms:abstract>
<dcterms:abstract xml:lang="en">[...]My specific aim are the following : 1. To determine the role of PKR1 signaling pathways in vivo ; 2. To show that the inactivation of PKR1 specifically in epicardium can induce cardiac and renal disorders ; 3. To determine the role of PKR1 in activation and differentiation of progenitor cells.[...]</dcterms:abstract>
<dc:type>Electronic Thesis or Dissertation</dc:type>
<dc:type xsi:type="dcterms:DCMIType">Text</dc:type>
<dc:language xsi:type="dcterms:RFC3066">fr</dc:language>
</tef:thesisRecord>
</mets:xmlData>
</mets:mdWrap>
</mets:dmdSec>
<mets:dmdSec ID="ABES.STAR.THESE_25455.VERSION_COMPLETE.DESCRIPTION.EDITION_ARCHIVAGE">
<mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_desc_edition">
<mets:xmlData>
<tef:edition>
<dcterms:medium xsi:type="dcterms:IMT">PDF</dcterms:medium>
<dcterms:extent>20248536</dcterms:extent>
<tef:editeur>
<tef:nom>Université de Strasbourg</tef:nom>
<tef:place>Strasbourg</tef:place>
</tef:editeur>
<dcterms:issued xsi:type="dcterms:W3CDTF">2013-12-31</dcterms:issued>
<dc:identifier xsi:type="dcterms:URI">https://theses.hal.science/tel-01070645</dc:identifier>
</tef:edition>
</mets:xmlData>
</mets:mdWrap>
</mets:dmdSec>
<mets:dmdSec ID="ABES.STAR.THESE_25455.VERSION_COMPLETE.DESCRIPTION.EDITION_1">
<mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_desc_edition">
<mets:xmlData>
<tef:edition>
<dcterms:medium xsi:type="dcterms:IMT">application/pdf</dcterms:medium>
<dcterms:extent>10348188</dcterms:extent>
<dc:identifier xsi:type="dcterms:URI">https://publication-theses.unistra.fr/public/theses_doctorat/2012/Boulberdaa_Mounia_2012_ED414.pdf</dc:identifier>
<dc:identifier xsi:type="dcterms:URI">http://www.theses.fr/2012STRAJ077/abes</dc:identifier>
<dc:identifier xsi:type="dcterms:URI">https://theses.hal.science/tel-01070645</dc:identifier>
<dc:identifier xsi:type="dcterms:URI">https://theses.hal.science/tel-01070645</dc:identifier>
<dc:identifier xsi:type="dcterms:URI">https://theses.hal.science/tel-01070645</dc:identifier>
<dc:identifier xsi:type="dcterms:URI">https://theses.hal.science/tel-01070645</dc:identifier>
<dc:identifier xsi:type="dcterms:URI">https://theses.hal.science/tel-01070645</dc:identifier>
</tef:edition>
</mets:xmlData>
</mets:mdWrap>
</mets:dmdSec>
<mets:amdSec>
<mets:techMD ID="ABES.STAR.THESE_25455.ADMINISTRATION">
<mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_admin_these">
<mets:xmlData>
<tef:thesisAdmin>
<tef:auteur>
<tef:nom>Boulberdaa</tef:nom>
<tef:prenom>Mounia</tef:prenom>
<tef:dateNaissance>1984-03-17</tef:dateNaissance>
<tef:nationalite scheme="ISO-3166-1">FR</tef:nationalite>
<tef:autoriteExterne autoriteSource="Sudoc">168419092</tef:autoriteExterne>
<tef:autoriteExterne autoriteSource="CODE_ETUDIANT">40301208</tef:autoriteExterne>
</tef:auteur>
<dc:identifier xsi:type="tef:nationalThesisPID">https://theses.fr/2012STRAJ077</dc:identifier>
<dc:identifier xsi:type="tef:NNT">2012STRAJ077</dc:identifier>
<dc:identifier xsi:type="tef:DOI">https://doi.org/10.70675/43d8af7cz6a4az408czab76z9dbafddea247</dc:identifier>
<dcterms:dateAccepted xsi:type="dcterms:W3CDTF">2012-09-13</dcterms:dateAccepted>
<tef:thesis.degree>
<tef:thesis.degree.discipline xml:lang="fr">Aspects moléculaires et cellulaires de la biologie</tef:thesis.degree.discipline>
<tef:thesis.degree.grantor>
<tef:nom>Strasbourg</tef:nom>
<tef:autoriteExterne autoriteSource="Sudoc">131056549</tef:autoriteExterne>
</tef:thesis.degree.grantor>
<tef:thesis.degree.level>Doctorat</tef:thesis.degree.level>
<tef:thesis.degree.name xml:lang="fr">Docteur es</tef:thesis.degree.name>
</tef:thesis.degree>
<tef:theseSurTravaux>non</tef:theseSurTravaux>
<tef:avisJury>oui</tef:avisJury>
<tef:directeurThese>
<tef:nom>Nebigil-Désaubry</tef:nom>
<tef:prenom>Canan</tef:prenom>
<tef:autoriteInterne>MADS_DIRECTEUR_DE_THESE_1</tef:autoriteInterne>
<tef:autoriteExterne autoriteSource="Sudoc">138947694</tef:autoriteExterne>
</tef:directeurThese>
<tef:presidentJury>
<tef:nom>Schini-Kerth</tef:nom>
<tef:prenom>Valérie</tef:prenom>
<tef:autoriteInterne>MADS_PRESIDENT_DU_JURY</tef:autoriteInterne>
</tef:presidentJury>
<tef:membreJury>
<tef:nom>Straehle</tef:nom>
<tef:prenom>Uwe</tef:prenom>
<tef:autoriteInterne>MADS_MEMBRE_DU_JURY_1</tef:autoriteInterne>
</tef:membreJury>
<tef:rapporteur>
<tef:nom>Pedrazzini</tef:nom>
<tef:prenom>Thierry</tef:prenom>
<tef:autoriteInterne>MADS_RAPPORTEUR_1</tef:autoriteInterne>
</tef:rapporteur>
<tef:rapporteur>
<tef:nom>Zaffran</tef:nom>
<tef:prenom>Stéphane</tef:prenom>
<tef:autoriteInterne>MADS_RAPPORTEUR_2</tef:autoriteInterne>
</tef:rapporteur>
<tef:ecoleDoctorale>
<tef:nom>École doctorale des Sciences de la vie et de la santé (Strasbourg ; 2000-....)</tef:nom>
<tef:autoriteInterne>MADS_ECOLE_DOCTORALE_1</tef:autoriteInterne>
<tef:autoriteExterne autoriteSource="Annuaire des formations doctorales et des unités de recherche">VS</tef:autoriteExterne>
<tef:autoriteExterne autoriteSource="Sudoc">156502844</tef:autoriteExterne>
</tef:ecoleDoctorale>
<tef:partenaireRecherche type="laboratoire">
<tef:nom>Biotechnologie et signalisation cellulaire (Strasbourg ; 2011-....)</tef:nom>
<tef:autoriteInterne>MADS_PARTENAIRE_DE_RECHERCHE_1</tef:autoriteInterne>
<tef:autoriteExterne autoriteSource="Annuaire des formations doctorales et des unités de recherche">FRE 3211</tef:autoriteExterne>
<tef:autoriteExterne autoriteSource="Sudoc">157715205</tef:autoriteExterne>
<tef:autoriteExterne autoriteSource="labTEL">207563</tef:autoriteExterne>
</tef:partenaireRecherche>
<tef:oaiSetSpec>ddc:570</tef:oaiSetSpec>
<tef:oaiSetSpec>ddc:610</tef:oaiSetSpec>
<tef:MADSAuthority authorityID="MADS_DIRECTEUR_DE_THESE_1" type="personal">
<tef:personMADS>
<mads:namePart type="family">Nebigil-Désaubry</mads:namePart>
<mads:namePart type="given">Canan</mads:namePart>
</tef:personMADS>
</tef:MADSAuthority>
<tef:MADSAuthority authorityID="MADS_PRESIDENT_DU_JURY" type="personal">
<tef:personMADS>
<mads:namePart type="family">Schini-Kerth</mads:namePart>
<mads:namePart type="given">Valérie</mads:namePart>
</tef:personMADS>
</tef:MADSAuthority>
<tef:MADSAuthority authorityID="MADS_MEMBRE_DU_JURY_1" type="personal">
<tef:personMADS>
<mads:namePart type="family">Straehle</mads:namePart>
<mads:namePart type="given">Uwe</mads:namePart>
</tef:personMADS>
</tef:MADSAuthority>
<tef:MADSAuthority authorityID="MADS_RAPPORTEUR_1" type="personal">
<tef:personMADS>
<mads:namePart type="family">Pedrazzini</mads:namePart>
<mads:namePart type="given">Thierry</mads:namePart>
</tef:personMADS>
</tef:MADSAuthority>
<tef:MADSAuthority authorityID="MADS_RAPPORTEUR_2" type="personal">
<tef:personMADS>
<mads:namePart type="family">Zaffran</mads:namePart>
<mads:namePart type="given">Stéphane</mads:namePart>
</tef:personMADS>
</tef:MADSAuthority>
<tef:MADSAuthority authorityID="MADS_ECOLE_DOCTORALE_1" type="corporate">
<tef:personMADS>
<mads:namePart type="family">École doctorale Sciences de la vie et de la santé (Strasbourg ; 2000-....)</mads:namePart>
</tef:personMADS>
</tef:MADSAuthority>
<tef:MADSAuthority authorityID="MADS_PARTENAIRE_DE_RECHERCHE_1" type="corporate">
<tef:personMADS>
<mads:namePart type="family">Biotechnologie et signalisation cellulaire (Strasbourg)</mads:namePart>
</tef:personMADS>
</tef:MADSAuthority>
</tef:thesisAdmin>
</mets:xmlData>
</mets:mdWrap>
</mets:techMD>
<mets:techMD ID="ABES.STAR.THESE_25455.VERSION_COMPLETE.EDITION_ARCHIVAGE.TECH_FICHIER.DOSSIER_1.DOSSIER_1.FICHIER_1">
<mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_tech_fichier">
<mets:xmlData>
<tef:meta_fichier>
<tef:formatFichier>PDF</tef:formatFichier>
<tef:taille>20248536</tef:taille>
</tef:meta_fichier>
</mets:xmlData>
</mets:mdWrap>
</mets:techMD>
<mets:rightsMD ID="ABES.STAR.THESE_25455.DROITS_UNIVERSITE">
<mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_etablissement_these">
<mets:xmlData>
<metsRights:RightsDeclarationMD RIGHTSCATEGORY="CONTRACTUAL">
<metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
<metsRights:Permissions COPY="false" DELETE="false" DISPLAY="true" DUPLICATE="true" MODIFY="false" PRINT="false"/>
<metsRights:Constraints CONSTRAINTTYPE="TIME">
<metsRights:ConstraintDescription>confidentialité 2012-09-13 2014-10-01</metsRights:ConstraintDescription>
</metsRights:Constraints>
</metsRights:Context>
<metsRights:Context CONTEXTCLASS="INSTITUTIONAL AFFILIATE">
<metsRights:Permissions COPY="false" DELETE="false" DISPLAY="true" DUPLICATE="true" MODIFY="false" PRINT="false"/>
<metsRights:Constraints CONSTRAINTTYPE="TIME">
<metsRights:ConstraintDescription>confidentialité 2012-09-13 2014-10-01</metsRights:ConstraintDescription>
</metsRights:Constraints>
</metsRights:Context>
</metsRights:RightsDeclarationMD>
</mets:xmlData>
</mets:mdWrap>
</mets:rightsMD>
<mets:rightsMD ID="ABES.STAR.THESE_25455.DROITS_DOCTORANT">
<mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_auteur_these">
<mets:xmlData>
<metsRights:RightsDeclarationMD RIGHTSCATEGORY="CONTRACTUAL">
<metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
<metsRights:Permissions COPY="false" DELETE="false" DISPLAY="true" DUPLICATE="true" MODIFY="false" PRINT="false"/>
<metsRights:Constraints CONSTRAINTTYPE="TIME">
<metsRights:ConstraintDescription>restriction 2012-09-13 2014-10-01</metsRights:ConstraintDescription>
</metsRights:Constraints>
</metsRights:Context>
<metsRights:Context CONTEXTCLASS="INSTITUTIONAL AFFILIATE">
<metsRights:Permissions COPY="false" DELETE="false" DISPLAY="true" DUPLICATE="true" MODIFY="false" PRINT="false"/>
</metsRights:Context>
</metsRights:RightsDeclarationMD>
</mets:xmlData>
</mets:mdWrap>
</mets:rightsMD>
<mets:rightsMD ID="ABES.STAR.THESE_25455.VERSION_COMPLETE.DROITS">
<mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_version">
<mets:xmlData>
<metsRights:RightsDeclarationMD RIGHTSCATEGORY="CONTRACTUAL">
<metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
<metsRights:Permissions COPY="false" DELETE="false" DISPLAY="true" DUPLICATE="true" MODIFY="false" PRINT="false"/>
<metsRights:Constraints CONSTRAINTTYPE="TIME">
<metsRights:ConstraintDescription>confidentialité 2012-09-13 2014-10-01</metsRights:ConstraintDescription>
</metsRights:Constraints>
</metsRights:Context>
<metsRights:Context CONTEXTCLASS="INSTITUTIONAL AFFILIATE">
<metsRights:Permissions COPY="false" DELETE="false" DISPLAY="true" DUPLICATE="true" MODIFY="false" PRINT="false"/>
<metsRights:Constraints CONSTRAINTTYPE="TIME">
<metsRights:ConstraintDescription>confidentialité 2012-09-13 2014-10-01</metsRights:ConstraintDescription>
</metsRights:Constraints>
</metsRights:Context>
</metsRights:RightsDeclarationMD>
</mets:xmlData>
</mets:mdWrap>
</mets:rightsMD>
</mets:amdSec>
<mets:fileSec>
<mets:fileGrp ID="ABES.STAR.THESE_25455.VERSION_COMPLETE.EDITION_ARCHIVAGE.FILEGRP" USE="archive">
<mets:file ADMID="ABES.STAR.THESE_25455.VERSION_COMPLETE.EDITION_ARCHIVAGE.TECH_FICHIER.DOSSIER_1.DOSSIER_1.FICHIER_1" ID="ABES.STAR.THESE_25455.VERSION_COMPLETE.EDITION_ARCHIVAGE.DOSSIER_1.DOSSIER_1.FICHIER_1" SEQ="1">
<mets:FLocat LOCTYPE="URL" xlink:href="STRA/THESE_25455/document/0/0/Boulberdaa_Mounia_2012_ED414_A.pdf"/>
</mets:file>
</mets:fileGrp>
</mets:fileSec>
<mets:structMap TYPE="logical">
<mets:div ADMID="ABES.STAR.THESE_25455.ADMINISTRATION ABES.STAR.THESE_25455.DROITS_UNIVERSITE ABES.STAR.THESE_25455.DROITS_DOCTORANT" CONTENTIDS="CONTENTIDS.ABES.STAR.THESE_25455" DMDID="ABES.STAR.THESE_25455.DESCRIPTION_BIBLIOGRAPHIQUE" TYPE="THESE">
<mets:div ADMID="ABES.STAR.THESE_25455.VERSION_COMPLETE.DROITS" CONTENTIDS="CONTENTIDS.ABES.STAR.THESE_25455.ABES.STAR.THESE_25455.VERSION_COMPLETE" TYPE="VERSION_COMPLETE">
<mets:div CONTENTIDS="CONTENTIDS.ABES.STAR.THESE_25455.VERSION_COMPLETE.EDITION_ARCHIVAGE" DMDID="ABES.STAR.THESE_25455.VERSION_COMPLETE.DESCRIPTION.EDITION_ARCHIVAGE" TYPE="EDITION">
<mets:fptr FILEID="ABES.STAR.THESE_25455.VERSION_COMPLETE.EDITION_ARCHIVAGE.FILEGRP"/>
</mets:div>
<mets:div CONTENTIDS="CONTENTIDS.ABES.STAR.THESE_25455.VERSION_COMPLETE.EDITION_1" DMDID="ABES.STAR.THESE_25455.VERSION_COMPLETE.DESCRIPTION.EDITION_1" TYPE="EDITION"/>
</mets:div>
</mets:div>
</mets:structMap>
</mets:mets>