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<dc:title xml:lang="en">Interventional MR Elastography for the monitoring of thermal ablations</dc:title>
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<dcterms:abstract xml:lang="fr">L'ablation thermique vise à endommager les cellules tumorales en chauffant ou en congelant le tissu tumoral. La surveillance par IRM est une technique prometteuse pour assurer la destruction des cellules tumorales tout en aidant à préserver les tissus sains environnants. L'équipe ICube a récemment proposé l'utilisation de l'élastographie RM en temps réel (MRE) et de la thermométrie RM (MRT). Cela permet de surveiller la température et les propriétés mécaniques du tissu ciblé simultanément en temps réel. Dans cette thèse de doctorat , nous avons présenté deux développements différents afin de surmonter certaines des limitations actuelles de la MRE et de la MRT interventionnelles, en termes d’extension à la couverture spatiale de la région ciblée et au développement d’une nouvelle méthode de surveillance des ablations thermiques pour tous les types de tissus mous, y compris les tissus adipeux. Ces contributions visent à améliorer la sécurité et l'efficacité de l'ablation thermique guidée par MR.</dcterms:abstract>
<dcterms:abstract xml:lang="en">Thermal ablation aims at damaging tumor cells by either heating or freezing tumoral tissue. MRI monitoring is a promising technique for ensuring the destruction of tumor cells while preserving the surrounding healthy tissue. Recently, the ICube team demonstrated the use of simultaneous realtime MR Elastography (MRE) and MR Thermometry (MRT). It allows monitoring temperature and mechanical properties of the targeted tissue simultaneously in realtime. In this Ph.D. thesis, we have presented two different developments in order to overcome some of the current limitations of interventional MRE and MRT, in terms of extending to the spatial coverage of the targeted region and developing a new method to monitor thermal ablations for all types of soft tissues, including fatty tissues. These contributions aim at improving the safety and efficiency of MR guided thermal ablation.</dcterms:abstract>
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