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<dc:title xml:lang="fr">Les maladies transmises par les tiques : pathogènes émergents et outils innovants appliqués à l'épidémiologie vectorielle et humaine</dc:title>
<dcterms:alternative xml:lang="en">Tick-borne diseases : emerging pathogens and innovative tools applied to vector and human epidemiology</dcterms:alternative>
<dc:subject xml:lang="fr">Tique</dc:subject>
<dc:subject xml:lang="fr">Ixodes</dc:subject>
<dc:subject xml:lang="fr">Maladies vectorielles à tiques</dc:subject>
<dc:subject xml:lang="fr">Syndromes fébriles après piqûre de tique</dc:subject>
<dc:subject xml:lang="fr">MALDI-TOF</dc:subject>
<dc:subject xml:lang="fr">Protéomique</dc:subject>
<dc:subject xml:lang="fr">Stratégie innovante</dc:subject>
<dc:subject xml:lang="fr">Borrelia miyamotoi</dc:subject>
<dc:subject xml:lang="fr">Neoehrlichia mikurensis</dc:subject>
<dc:subject xml:lang="en">Ticks</dc:subject>
<dc:subject xml:lang="en">Ixodes</dc:subject>
<dc:subject xml:lang="en">Tick-borne diseases</dc:subject>
<dc:subject xml:lang="en">Post-tick bite fever</dc:subject>
<dc:subject xml:lang="en">MALDI-TOF</dc:subject>
<dc:subject xml:lang="en">Proteomic</dc:subject>
<dc:subject xml:lang="en">Innovative strategy</dc:subject>
<dc:subject xml:lang="en">Borrelia miyamotoi</dc:subject>
<dc:subject xml:lang="en">Neoehrlichia mikurensis</dc:subject>
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<dcterms:abstract xml:lang="fr">Les tiques représentent les premiers vecteurs d’agents infectieux pour la médecine vétérinaire et humaine dans le monde. De nombreux microorganismes peuvent être détectés dans les tiques. Cependant, seules certaines tiques peuvent être vectrices de microorganismes et seuls certains microorganismes peuvent être transmis par les tiques et présenter un risque pour l’homme. Ce travail de thèse s’articule autour de trois axes concernant les tiques et les maladies vectorielles à tiques. Le premier axe s’intéresse au développement de la technologie MALDI-TOF pour l’identification des tiques vectrices de microorganismes. Le deuxième axe étudie deux agents infectieux émergents transmis par les tiques : Borrelia miyamotoi et Neoehrlichia mikurensis décrits comme responsables de fièvres après piqûre de tique. Enfin, le troisième axe est un travail préliminaire de mise au point d’une technique diagnostique par protéomique des fièvres après piqûre de tique (collab. LSMBO Pr L. Sabatier).</dcterms:abstract>
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