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<dc:title xml:lang="en">Coevolution of sociality and ageing in animal societies</dc:title>
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<dc:subject xml:lang="fr">Insectes sociaux</dc:subject>
<dc:subject xml:lang="fr">Fourmis</dc:subject>
<dc:subject xml:lang="fr">Oiseaux</dc:subject>
<dc:subject xml:lang="fr">Télomères</dc:subject>
<dc:subject xml:lang="fr">Stress oxydant</dc:subject>
<dc:subject xml:lang="fr">Omique</dc:subject>
<dc:subject xml:lang="fr">Évolution</dc:subject>
<dc:subject xml:lang="en">Social insects</dc:subject>
<dc:subject xml:lang="en">Ants</dc:subject>
<dc:subject xml:lang="en">Birds</dc:subject>
<dc:subject xml:lang="en">Telomeres</dc:subject>
<dc:subject xml:lang="en">Oxidative stress</dc:subject>
<dc:subject xml:lang="en">Omics</dc:subject>
<dc:subject xml:lang="en">Evolution</dc:subject>
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<tef:elementdEntree autoriteExterne="031229522" autoriteSource="Sudoc">Effets du stress</tef:elementdEntree>
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<dcterms:abstract xml:lang="fr">Ma thèse analyse comment l’environnement social influence la longévité chez des espèces animales variées (vertébrées et invertébrés) montrant un gradient de complexité sociale (grégarisme, élevage coopératif, eusocialité). Grâce à des mesures complémentaires (observations comportementales, stress oxydant, longueur des télomères, protéomique, métabolomique), mon travail reflète des mécanismes de vieillissement contrastés selon les espèces étudiées. Par exemple chez les oiseaux, des télomères plus longs sont associés à un environnement social favorable et à une plus grande longévité. Au contraire, parmi les 10 espèces de fourmis étudiées, les plus longévives présentaient des télomères plus courts. Par ailleurs l’étude complète et combinée du protéome et du métabolome de fourmis a mis en évidence certains mécanismes (e.g. sirtuines, mTOR, anticancéreux) dont l’universalité ouvre la voie à une meilleure compréhension de l’effet néfaste du stress social sur la santé humaine.</dcterms:abstract>
<dcterms:abstract xml:lang="en">My thesis analyses how the social environment influences longevity in various animal species (vertebrates and invertebrates) in a gradient of social complexity (gregariousness, cooperative breeding, eusociality). Thanks to complementary measurements (behavioural observations, oxidative stress, telomere length, proteomics, metabolomics), my work reflects contrasting ageing mechanisms depending on the species studied. For example, in birds, longer telomeres are associated with a favourable social environment and greater longevity. On the contrary, among the 10 species of ants studied, the longest-lived ants had shorter telomeres. Furthermore, the complete and combined study of the proteome and metabolome of ants has highlighted certain mechanisms (e.g., sirtuins, mTOR, anti-cancer mechanisms), the universality of which opens the way to a better understanding of the harmful effect of social stress on human health.</dcterms:abstract>
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