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<dc:title xml:lang="fr">Bio-ingénierie d'une molaire et son innervation après implantation en site osseux</dc:title>
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<dc:subject xml:lang="fr">Régénération dentaire</dc:subject>
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<dc:subject xml:lang="en">Tooth regeneration</dc:subject>
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<dcterms:abstract xml:lang="fr">La régénération tissulaire est un domaine en pleine expansion en odontologie et a pour principal objectif de remplacer les tissus dentaires lésés ou absents. Il existe différentes approches basées sur la régénération d'un type tissulaire particulier constituant la dent (émail, dentine, pulpe), du parodonte (cément, os alvéolaire, ligament alvéolo-dentaire) ou encore d'une dent entière. Dans cette perspective, la vascularisation et l'innervation de la dent sont essentielles pour le maintien de l'homéostasie et la réponse aux stimuli nociceptifs. Ce travail de thèse s’articule autour de trois grandes thématiques : la régénération de la dent et son innervation, la préparation d’un site osseux propice à son développement et enfin son éruption dans la cavité buccale, la régénération tissulaire n’ayant de sens que lorsque l’organe est fonctionnel.</dcterms:abstract>
<dcterms:abstract xml:lang="en">Tissue regeneration is a rapidly expanding field in dentistry and its main objective is to replace damaged or absent dental tissue. There are different approaches based on the regeneration of a particular type of tissue constituting the tooth (enamel, dentin, pulp), the periodontium (cement, alveolar bone, periodontal ligament) or even an entire tooth. In this perspective, the vascularization and innervation of the tooth are essential for the maintenance of homeostasis and the response to nociceptive stimuli. This work revolves around three main themes: the regeneration of the tooth and its innervation, the preparation of a bone site conducive to its development and finally its eruption in the oral cavity.</dcterms:abstract>
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