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<dc:title xml:lang="fr">Bases cérébrales et cognitives de la tolérance sociale chez les macaques</dc:title>
<dcterms:alternative xml:lang="en">Neural and cognitive bases of social tolerance in macaques</dcterms:alternative>
<dc:subject xml:lang="fr">Primate non-humain</dc:subject>
<dc:subject xml:lang="fr">Tolérance sociale</dc:subject>
<dc:subject xml:lang="fr">Cerveau social</dc:subject>
<dc:subject xml:lang="fr">Neuroanatomie comparative</dc:subject>
<dc:subject xml:lang="en">Non-human primate</dc:subject>
<dc:subject xml:lang="en">Social tolerance</dc:subject>
<dc:subject xml:lang="en">Social brain</dc:subject>
<dc:subject xml:lang="en">Comparative neuroanatomy</dc:subject>
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<dcterms:abstract xml:lang="fr">Chez les macaques, la tolérance sociale varie, selon les espèces, du despotisme (grade 1) à une forte tolérance (grade 4). Cette thèse explore les bases neuroanatomiques, fonctionnelles et cognitives de cette variabilité via une approche comparative centrée sur le cerveau social. Une étude post-mortem sur 43 cerveaux de 12 espèces montre que l’amygdale est plus volumineuse chez les espèces tolérantes, avec un effet modulant de l’âge. L’analyse de la morphologie sulcale du cortex frontal médian révèle des variations significatives de taille et de présence de certains sillons, notamment du VPCGS-A, associées au grade social. En parallèle, une IRMf de repos menée in vivo chez M. mulatta (G1) et M. tonkeana (G4), vivant en semi-liberté, confirme la robustesse de réseaux fonctionnels homologues déjà décrits chez le macaque (notamment le DMN) et établit un protocole inédit en contexte écologique. Enfin, une revue conceptuelle propose un cadre opérationnel pour définir et étudier la confiance chez les primates. Ces travaux apportent de nouvelles connaissances sur l’organisation du cerveau social chez les macaques.</dcterms:abstract>
<dcterms:abstract xml:lang="en">In macaques, social tolerance varies across species, ranging from despotic (grade 1) to highly tolerant (grade 4). This thesis explores the neuroanatomical, functional, and cognitive bases of this variability through a comparative approach centered on the social brain. A post-mortem study of 43 brains from 12 species shows that the amygdala is larger in tolerant species, with a modulatory effect of age. Analysis of sulcal morphology in the medial frontal cortex reveals significant differences in the size and presence of certain sulci, notably the VPCGS-A, associated with social grade. In parallel, a resting-state fMRI study conducted in vivo on M. mulatta (G1) and M. tonkeana (G4), living in semi-freedom, confirms the robustness of functional networks homologous to those previously described in macaques (notably the DMN) and establishes a novel protocol in ecological conditions. Finally, a conceptual review proposes an operational framework to define and study trust in primates. Together, these findings provide new insights into the organization of the social brain in macaques.</dcterms:abstract>
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