Identification and characterization of the biological activity of anticancer organometallic compounds
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Author : Licona, Cynthia
Date : 24-04-2015

Research director(s) : Mellitzer, Georg - Gaiddon, Christian

???xsl.tef.president??? : Dontenwill, Monique
Rapporteur(s) : Chevet, Éric - Casini, Angela
Membre(s) du jury : Sadler, Peter

Institution : Strasbourg
Laboratory : Interface de recherche fondamentale et appliquée en cancérologie (Strasbourg ; 2...-2023)
Doctoral school : École doctorale des Sciences de la vie et de la santé (Strasbourg ; 2000-....)
 
Discipline : Aspects moléculaires et cellulaires de la biologie
Classification : Life sciences, biology, biochemistry, Medicine and health

Keyword(s) : Organometallic compounds, Ruthenium, Osmium, Redox potential, Cytotoxicity, Hif1, HDAC, NRF2
Keyword(s) :
  • Composés organométalliques - Relations structure-activité
  • Composés organométalliques - Emploi en thérapeutique -- Effets secondaires
  • Cancer -- Thérapeutique
  • Toxicologie cellulaire
Abstract : Cancer is one of the leading causes of death in the world. To treat cancer, several therapeutic approaches exist. Chemotherapy in combination with surgery is one of the most used. Organometallic compounds such as platinum salts represent a reference in clinic. Despite their success, they have limitations that are toxicity to healthy tissue and the development of resistance. Our team has been working for several years with chemists to develop new organometallic Ruthenium (ROC) and Osmium compounds (ODC). During my Ph.D. I performed structure/function studies on novel molecules in order to find the important physico chemical parameters for their biological activity. My work demonstrated that the redox potential is a crucial factor for the cytotoxicity of the compounds. ln addition, I identified novel regulatory pathways that are targeted by these compounds, such as the Hif1 and Nrf2 pathways, and the HDACs. All together these results allow us to have a better understanding of the biological properties of the organometallic compounds, which will in time allow a optimization of their structure to favor their anticancer activity.
 
Content type : Text
Format : PDF
 
Repository : STAR : dépôt national des thèses électroniques françaises
Identifier : 2015STRAJ017
Document type : TEF